Xenopus - From Basic Biology to Disease Models in the Genomic Era

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    This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences.... Toon meer
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    AuteursAbraham Fainsod & Sally A. Moody
    UitgeverCRC Press
    Formaat209 x 278 x 23 mm
    AfbeeldingenLijntekeningen en tabellen
    Jaar van uitgave  2022

    This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.

    Key Features:

    • Provides historical context of the contributions of the model system
    • Includes contributions from an international team of leading scholars
    • Presents topics spanning cell biology, developmental biology, genomics, and disease model
    • Describes recent experimental advances
    • Incorporates richly illustrated diagrams and color images

    Table of Contents


    Section I: Contributions to Cell, Developmental and Molecular Biology

    Chapter 1: A quick history of Xenopus: The humble batrachian
    John B. Wallingford

    Chapter 2: The study of cell division control and DNA replication in Xenopus egg extracts
    Allison M. Jevitt and Susannah Ranki

    Chapter 3: Maternal gene control of embryogenesis: germ cell determination and germ layer formation
    Douglas W. Houston

    Chapter 4: Signaling components in dorsal-ventral patterning and the Organizer in Xenopus
    Eddy M. De Robertis and Nydia Tejeda-Munoz

    Chapter 5: Signaling pathways in anterior-posterior patterning
    Chenbei Chang

    Chapter 6: Wnt signaling in tissue differentiation and morphogenesis
    Stefan Hoppler and Michael Kuhl

    Chapter 7: Multiple functions of Notch signaling during early embryogenesis
    Silvia L. Lopez

    Chapter 8: The development and evolution of the vertebrate neural crest: insights from Xenopus
    Joshua R. York and Carole LaBonne

    Chapter 9: The use of Xenopus oocytes to study the biophysics and pharmacological properties of receptors and channels
    Ataulfo Martinez-Torres and Elizabeth Pereida-Jaramillo

    Section II: Systems Biology and the Genomic Era

    Chapter 10: The continuing evolution of the Xenopus genome
    Mariko Kondo and Masanori Taira

    Chapter 11: Dynamics of chromatin remodeling during Xenopus development
    Gert Jan C. Veenstra

    Chapter 12: Gene regulatory networks controlling Xenopus embryogenesis
    Ken W. Y. Cho and Ira L. Blitz

    Chapter 13: Development of high-resolution proteomic analyses in Xenopus
    Elizabeth Van Itallie and Leonid Peshkin

    Chapter 14: Advances in genome editing tools
    Marko E. Horb, Anita Abu-Daya, Marcin Wlizla, Anna Noble and Matt Guille

    Section III: From Basic Biological Insights to Human Disease

    Chapter 15: Formation of the left-right axis: insights from the Xenopus model
    Axel Schweickert and Tim Ott

    Chapter 16: Discovering the function of congenital heart disease genes
    Delfina P. Gonzalez and Mustafa K. Khokha

    Chapter 17: Craniofacial development and disorders: contributions of Xenopus
    Ashwin Lokapally and Hazel Sive

    Chapter 18: Modeling digestive and respiratory system development and disease in Xenopus
    Scott A. Rankin and Aaron M. Zorn

    Chapter 19: Functional neurobiology in Xenopus provides insights into health and disease
    Clayton Gordy, Michael Forsthofer, Parthena Soupiadou, Suzan Ozugur and Hans Straka

    Chapter 20: Leaping towards the understanding of spinal cord regeneration
    Paula Slater, Gabriela Edwards-Faret and Juan Larrain

    Chapter 21: Studying tumor formation and regulation in Xenopus
    Dieter Tulkens and Kris Vlemnickx

    Chapter 22: Xenopus: a model to study natural genetic variation and its disease implications
    Avi Leibovich, Sally A. Moody, Steven L. Klein and Abraham Fainsod

    Chapter 23: Using Xenopus to understand pluripotency and reprogram cells for therapeutic use
    Meghana S. Oak and Eva Hörmanseder




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